Suddenly getting boot failures -- AppleUSBHostPort :: createDevice: failed to create device

I've had my current hack running for more than a year. Closer to 18 months.

Suddenly (today) it refuses to boot and gives me the following error:
AppleUSB20XHCIPort@14e00000: AppleUSBHostPort : :createDevice: failed to create device (0xe00002bc)

That line shows four to six times--it's different each time, then it stops at:
AppleUSB20XHCIPort@14e00000: AppleUSBHostPort : :disconnect : persistent enumeration failures

Googling gives various results -- it seems this can be caused...

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