Optimal drive setup for dual-boot video rig? General filesystem discussion...

I'm in the preliminary stages of building a hackintosh for video editing. I haven't decided on a CPU/mobo combo yet (will probably save that for another post) but I have taken advantage of some recent sales and wanted to see if I was on track with my thinking about a dual-boot setup.

These are drives I bought:

Samsung 860 EVO 500GB 2.5 Inch SATA III Internal SSD (MZ-76E500B/AM)

Samsung 970 EVO 500GB - NVMe PCIe M.2 2280 SSD (MZ-V7E500BW)

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Samsung 860 EVO 1TB 2.5 Inch SATA III Internal SSD (MZ-76E1T0B/AM)

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Seagate Barracuda Internal Hard Drive 4TB SATA 6Gb/s 256MB Cache 3.5-Inch (ST4000DM004)

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I am thinking about installing macOS on the 500GB SSD, pointing my home folder to the 500GB NVME drive, using the 1TB SSD for Windows, and using the 4TB for backup/Time Machine (will probably further back up to a NAS at a later point.) From what I understand, more benefit will come from using the NVME for working files as opposed to boot disk. I think 500GB should be plenty for boot disk for a while. Most of the space on my 500GB MBP is going to user files (with Adobe Creative Suite and several audio programs installed.) I should have room to grow, even accounting for video libraries that may be included as default for some programs. I will probably install Sierra or High Sierra to ensure compatibility with programs that are not quite current. If possible, it would be nice to have a separate Mojave volume on the same SSD. For now most of my video projects will be relatively lightweight so I plan to archive to external drives as needed and just use my Documents folder on NVME for active/recent projects.

I will use the 1TB for windows, using virtual machines and possibly partitioning to explore linux further. I may create an exFAT volume to use as a "mezzanine" disk to transfer info between systems if this makes sense. I have Paragon NTFS for Mac on my MacBook Pro and have used Paragon HFS+ on my Dell laptop to access external drives but I have read these utilities could cause instability if used extensively.

Having said all that here are some questions I have:

1. Does this make sense? Are there any gotchas or caveats I haven't considered that often crop up? I read the forums extensively but am still piecing it all together. I plan on using Carbon Copy Cloner to clone a base system once I get it working (along with incremental steps.) I will manually copy EFI
2. What filesystem should I use for macOS? Should I stick to HFS+on High Sierra? Can I partition the SSD and create a separate APFS container to dual-boot into Mojave with Clover? Or would it be best to just use a separate drive if I want to try Mojave?
3. What's the deal with NVME slots on the motherboard? I'm a little confused about how many NVME drives I can install. It seems some motherboards only have one slot for full NVME speeds? Do the limited PCI-E lanes on LGA 1151 boards have an impact? I bought a Sapphire RX Vega 64 but will probably return it for a RX 580 since it seems to be generally smoother.

Thanks in advance for any advice!

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