Hackintosh on a SATA M.2 drive - Can I use an M.2 USB enclosure to boot it?

Currently running 10.13 on a Ryzen 5 2600, Asus ROG Strix B450-I Motherboard. The OS and Clover are installed on its own 500GB Samsung 860 SATA M.2 drive. Can I install the drive in an M.2 USB enclosure like this and boot using of it?

submitted by /u/Kitty_Messiah
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