Could Hackintoshing cause damage?

I recently got a new Framework laptop, that I am using with an RX 6600 Thunderbolt eGPU. From what I have read so far, if I spoof the CPU (it's 13th Gen) I should be able to run macOS on this. I wouldn't intend to use it as a daily driver, rather as a fun little project.

Now I don't really care about having to do a ton of tinkering, or failing, but when hackintoshing my previous laptop (ThinkPad x280) I had read that in this case a misconfigured bios could cause you to brick the device.

Really this is the only thing deterring me from trying, so now my question is, is there a significant risk involved with trying to hackintosh this? Could I be causing permanent damage to my device if I try?